Once you have added your Skill Cluster framework, you can provide skill profile feedback using those Skill Clusters as well!

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Feedback with Skill Clusters

For example, if you want to add the Skill Cluster Data Science Modelling to a given Employees skill profile, you can send the following PUT to employees/<external_id>/skill_profile with query parameter feedback_format=skill_clusters. 
{
  "skill_clusters": [
    {
      "skill_clusters_name": "Data Science Modelling",
      "proficiency_level": 2
    }
  ]
}
Note that for the Skill Cluster feedback, you only have to send the Data Science Modelling Skill Cluster (& not the existing Skill Clusters in the skill profile).